Preheat oven to 350° F. Line a cupcake pan with 12 cupcake liners.
In a large mixing bowl, whisk together all-purpose flour, granulated sugar, baking powder, salt, and pumpkin pie spice.
Add in pumpkin puree, milk, vegetable oil, egg, and vanilla extract. Whisk the wet ingredients into the dry ingredients until full incorporated. Do not overmix.
Portion the cupcake batter into the cupcake liners ¾ full using a large cookie scoop for even cupcakes.
Bake for 20 minutes or until the tops of the cupcakes bounce back slightly when touched or an inserted toothpick comes out clean.
Remove the pan from the oven and allow the cupcakes to cool in the pan for a few minutes before transferring to a wire rack to cool completely.